RT Journal Article
SR Electronic
T1 Antibacterial action of the urease inhibitor acetohydroxamic acid on Helicobacter pylori.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 372
OP 373
DO 10.1136/jcp.46.4.372
VO 46
IS 4
A1 K Phillips
A1 D J Munster
A1 R A Allardyce
A1 P F Bagshaw
YR 1993
UL http://jcp.bmj.com/content/46/4/372.abstract
AB The urease inhibitor acetohydroxamic acid (AHA) was assessed for its bacteriostatic and bactericidal effects on Helicobacter pylori. For eight isolates of H pylori, the minimum inhibitory concentration (MIC) was either 200 mg/l or 400 mg/l. Interactions between AHA and antimicrobial drugs used to treat H pylori were also determined. For most isolates AHA reduced the MIC for colloidal bismuth subcitrate (CBS), tetracycline, metronidazole, and amoxicillin. In a few isolates, however, AHA increased the minimum bactericidal concentration (MBC) for these antimicrobial treatments. In vitro AHA is active against H pylori and it interacts with other agents directed against H pylori.