RT Journal Article SR Electronic T1 p53 expression in three separate tumours from a patient with Li-Fraumeni's syndrome. JF Journal of Clinical Pathology JO J Clin Pathol FD BMJ Publishing Group Ltd and Association of Clinical Pathologists SP 676 OP 677 DO 10.1136/jcp.46.7.676 VO 46 IS 7 A1 P King A1 A W Craft A1 A J Malcolm YR 1993 UL http://jcp.bmj.com/content/46/7/676.abstract AB The Li-Fraumeni cancer syndrome is a rare autosomal dominant syndrome, characterised by the occurrence of diverse mesenchymal and epithelial neoplasms at multiple sites. It has recently been shown that some of these individuals have a germ line mutation of the p53 tumour suppressor gene. The case of one member of such a family who has now developed three separate primary malignant tumours is reported. All three tumours expressed mutant p53 protein.