PT - JOURNAL ARTICLE AU - J E Crabtree AU - N Figura AU - J D Taylor AU - M Bugnoli AU - D Armellini AU - D S Tompkins TI - Expression of 120 kilodalton protein and cytotoxicity in Helicobacter pylori. AID - 10.1136/jcp.45.8.733 DP - 1992 Aug 01 TA - Journal of Clinical Pathology PG - 733--734 VI - 45 IP - 8 4099 - http://jcp.bmj.com/content/45/8/733.short 4100 - http://jcp.bmj.com/content/45/8/733.full SO - J Clin Pathol1992 Aug 01; 45 AB - Antral biopsy culture supernatants from 14 subjects with chronic gastritis, known to have IgA antibodies to the 120 kilodalton protein, showed positive recognition of this antigen in western blots against a cytotoxin positive strain of Helicobacter pylori but gave negative reactions with two cytotoxin negative strains. Control immunoblots with culture supernatants from 13 non-responders to the protein were all negative. This indicates a direct association between expression of the 120 kilodalton protein in H pylori strains and cytotoxicity.