TY - JOUR T1 - Serological differentiation between acute (late control) and endocarditis Q fever. JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 411 LP - 414 DO - 10.1136/jcp.46.5.411 VL - 46 IS - 5 AU - F Soriano AU - M T Camacho AU - C Ponte AU - P Gómez Y1 - 1993/05/01 UR - http://jcp.bmj.com/content/46/5/411.abstract N2 - AIMS--To differentiate the serological profiles of chronic (endocarditis) Q fever from the late follow up of acute cases. METHODS--Twenty patients (10 diagnosed with acute and 10 with endocarditis Q fever) were studied. Those diagnosed with acute infection were followed up from 2.5 to 88 months (mean 35.8 months). Serological variables included indirect immunofluorescence against phase I and II of Coxiella burnetii (IgM, IgG, and IgA), complement fixation and rheumatoid factor (RF). RESULTS--All patients with titres of IgA against phase I, after IgG removal, equal to or above 320 and a complement fixation value equal to or above 128 had endocarditis. No patient with acute Q fever had such a serological profile. CONCLUSIONS--The combination of IgA against phase I and complement fixation values may be sufficient to differentiate the serological profile of chronic (endocarditis) Q fever from the late follow up of acute cases. ER -