@article {Allain453, author = {P Allain and S Berre and N Krari and P Lain{\'e}-Cessac and A Le Bouil and N Barbot and V Rohmer and J C Bigorgne}, title = {Use of plasma iodine assay for diagnosing thyroid disorders.}, volume = {46}, number = {5}, pages = {453--455}, year = {1993}, doi = {10.1136/jcp.46.5.453}, publisher = {BMJ Publishing Group}, abstract = {AIMS--To examine the advantage of systematic plasma iodine assays in establishing the thyroid function of patients with thyroid disorders. METHODS--Iodine was determined by inductively coupled plasma mass spectrometry (ICPMS) in the plasma of 799 patients consulting for possible thyroid disorders, indicated by FT4 and TSH assays. RESULTS--Plasma iodine was below 40 micrograms/l in 57 (7\%) patients, most of whom had hypothyroidism; 40-80 micrograms/l in 439 (55\%) patients, most of whom had normal thyroid hormone function; 80-250 micrograms/l in 240 (30\%) patients, most of whom had hyperthyroidism; and above 250 micrograms/l in 63 (8\%) patients, almost all of whom had iodine overload caused by iodinated drugs, particularly amiodarone, resulting in euthyroidism (24\%), hyperthyroidism (36\%), and hypothyroidism (16\%). Sixty five (7\%) had been treated with amiodarone and 27 (3\%) with other iodinated drugs. More than 10\% of patients with thyroid disorders therefore had an iodine overload. CONCLUSIONS--The determination of total plasma iodine using the simple, accurate ICPMS technique, should be carried out in patients consulting for thyroid disorders, particularly for the detection of an iodine overload.}, issn = {0021-9746}, URL = {https://jcp.bmj.com/content/46/5/453}, eprint = {https://jcp.bmj.com/content/46/5/453.full.pdf}, journal = {Journal of Clinical Pathology} }