RT Journal Article
SR Electronic
T1 Atypical progression of multiple myeloma with extensive extramedullary disease.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 269
OP 271
DO 10.1136/jcp.47.3.269
VO 47
IS 3
A1 S N Jowitt
A1 A Jacobs
A1 P A Batman
A1 D A Sapherson
YR 1994
UL http://jcp.bmj.com/content/47/3/269.abstract
AB Multiple myeloma is a neoplastic disorder caused by the proliferation of a transformed B lymphoid progenitor cell that gives rise to a clone of immunoglobulin-secreting cells. Other plasma cell tumours include solitary plasmacytoma of bone (SPB) and extramedullary plasmacytomas (EMP). Despite an apparent common origin there exist pathological and clinical differences between these neoplasms and the association between them is not completely understood. A case of IgG multiple myeloma that presented with typical clinical and laboratory features, including a bone marrow infiltrated by well differentiated plasma cells, is reported. The tumour had an unusual evolution, with the development of extensive extramedullary disease while maintaining mature histological features.