TY - JOUR T1 - p53 expression in anaplastic carcinomas arising from thyroid papillary carcinomas. JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 337 LP - 339 DO - 10.1136/jcp.47.4.337 VL - 47 IS - 4 AU - X Matias-Guiu AU - M Cuatrecasas AU - E Musulen AU - J Prat Y1 - 1994/04/01 UR - http://jcp.bmj.com/content/47/4/337.abstract N2 - AIM--To study the expression of p53 tumour suppressor gene in anaplastic carcinomas arising from thyroid papillary carcinomas. METHODS--Formalin fixed, paraffin wax embedded tissues from four cases of anaplastic carcinomas associated with thyroid papillary carcinomas were studied by immunohistochemistry with two different p53 monoclonal antibodies. RESULTS--The anaplastic component showed nuclear immunostaining in two cases, but not in the other two. In all cases the papillary carcinoma component was negative. CONCLUSION--The results support the hypothesis that p53 stimulates tumour progression in thyroid tumours. ER -