PT  - JOURNAL ARTICLE
AU  - S H Lin
AU  - N A Sourial
AU  - K C Lu
AU  - E J Hsueh
TI  - Imerslund-Grasbeck syndrome in a Chinese family with distinct skin lesions refractory to vitamin B12.
AID  - 10.1136/jcp.47.10.956
DP  - 1994 Oct 01
TA  - Journal of Clinical Pathology
PG  - 956--958
VI  - 47
IP  - 10
4099  - http://jcp.bmj.com/content/47/10/956.short
4100  - http://jcp.bmj.com/content/47/10/956.full
SO  - J Clin Pathol1994 Oct 01; 47
AB  - Two brothers in a Chinese family with selective malabsorption of vitamin B12 associated with proteinuria (Imerslund-Grasbeck syndrome) presented with widespread mottled skin pigmentation, termed poikiloderma. In contrast to anaemia, this pigmentary disturbance remained unresponsive to vitamin B12 replacement. This is different from the reported hyperpigmentation sometimes seen in vitamin B12 deficiency which is reversible following treatment. As far as is known, an irreversible and persistent skin disorder has not been reported in this syndrome before.