TY - JOUR T1 - Imerslund-Grasbeck syndrome in a Chinese family with distinct skin lesions refractory to vitamin B12. JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 956 LP - 958 DO - 10.1136/jcp.47.10.956 VL - 47 IS - 10 AU - S H Lin AU - N A Sourial AU - K C Lu AU - E J Hsueh Y1 - 1994/10/01 UR - http://jcp.bmj.com/content/47/10/956.abstract N2 - Two brothers in a Chinese family with selective malabsorption of vitamin B12 associated with proteinuria (Imerslund-Grasbeck syndrome) presented with widespread mottled skin pigmentation, termed poikiloderma. In contrast to anaemia, this pigmentary disturbance remained unresponsive to vitamin B12 replacement. This is different from the reported hyperpigmentation sometimes seen in vitamin B12 deficiency which is reversible following treatment. As far as is known, an irreversible and persistent skin disorder has not been reported in this syndrome before. ER -