PT  - JOURNAL ARTICLE
AU  - D P O'Brien
AU  - D B Gough
AU  - R Skehill
AU  - H Grimes
AU  - H F Given
TI  - Simple method for comparing reliability of two serum tumour markers in breast carcinoma.
AID  - 10.1136/jcp.47.2.134
DP  - 1994 Feb 01
TA  - Journal of Clinical Pathology
PG  - 134--137
VI  - 47
IP  - 2
4099  - http://jcp.bmj.com/content/47/2/134.short
4100  - http://jcp.bmj.com/content/47/2/134.full
SO  - J Clin Pathol1994 Feb 01; 47
AB  - AIMS--To compare the two breast tumour markers, CA15-3 and mucinous-like carcinoma associated antigen (MCA), using Receiver Operating Characteristic (ROC) curve analysis. METHODS--One hundred and ninety six patients "presenting" with breast carcinoma had serum CA15-3 and MCA concentrations measured. RESULTS--Using these markers as indicators of stage IV disease at the recommended laboratory level, true positive rates (TPR) and false positive rates (FPR) were obtained as follows: CA15-3 TPR = 75%, FPR = 7.4%, MCA TPR = 80%, FPR = 59.1%. By increasing the CA15-3 cutoff level to 45 U/ml, a TPR and FPR of 75% and 0.6%, respectively were obtained. By increasing the MCA cutoff level to 23 U/ml, a TPR and FPR of 65% and 2.3%, respectively, were obtained. CONCLUSIONS--Using ROC curve analysis shows that CA15-3 is a superior indicator of metastatic breast disease than MCA at recommended laboratory levels, and by altering the cutoff points, the specificity and sensitivity for both these markers can be improved.