TY - JOUR T1 - Simple method for comparing reliability of two serum tumour markers in breast carcinoma. JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 134 LP - 137 DO - 10.1136/jcp.47.2.134 VL - 47 IS - 2 AU - D P O'Brien AU - D B Gough AU - R Skehill AU - H Grimes AU - H F Given Y1 - 1994/02/01 UR - http://jcp.bmj.com/content/47/2/134.abstract N2 - AIMS--To compare the two breast tumour markers, CA15-3 and mucinous-like carcinoma associated antigen (MCA), using Receiver Operating Characteristic (ROC) curve analysis. METHODS--One hundred and ninety six patients "presenting" with breast carcinoma had serum CA15-3 and MCA concentrations measured. RESULTS--Using these markers as indicators of stage IV disease at the recommended laboratory level, true positive rates (TPR) and false positive rates (FPR) were obtained as follows: CA15-3 TPR = 75%, FPR = 7.4%, MCA TPR = 80%, FPR = 59.1%. By increasing the CA15-3 cutoff level to 45 U/ml, a TPR and FPR of 75% and 0.6%, respectively were obtained. By increasing the MCA cutoff level to 23 U/ml, a TPR and FPR of 65% and 2.3%, respectively, were obtained. CONCLUSIONS--Using ROC curve analysis shows that CA15-3 is a superior indicator of metastatic breast disease than MCA at recommended laboratory levels, and by altering the cutoff points, the specificity and sensitivity for both these markers can be improved. ER -