RT Journal Article
SR Electronic
T1 Morphological transformation of Helicobacter pylori during prolonged incubation: association with decreased acid resistance.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 172
OP 174
DO 10.1136/jcp.47.2.172
VO 47
IS 2
A1 M Moshkowitz
A1 A Gorea
A1 N Arber
A1 F Konikoff
A1 S Berger
A1 T Gilat
YR 1994
UL http://jcp.bmj.com/content/47/2/172.abstract
AB The survival of clinical isolates of H pylori at two cultural ages (two and four days) at pH 2, in the presence of different buffers, with and without urea, was investigated. It was found that the morphological changes which occur with longer incubation of H pylori have an inverse correlation with its resistance to an acidic environment. The finding that the addition of urea almost reversed this phenomenon and prolonged survival of the cultures emphasises the role of urea in the survival of H pylori in acidic environments.