@article {Hammerling802, author = {J A Hammerling and R S Lambrecht and K S Kehl and D R Carrigan}, title = {Prevalence of human herpesvirus 6 in lung tissue from children with pneumonitis.}, volume = {49}, number = {10}, pages = {802--804}, year = {1996}, doi = {10.1136/jcp.49.10.802}, publisher = {BMJ Publishing Group}, abstract = {AIMS/BACKGROUND: Human herpesvirus type 6 (HHV-6) is the aetiological agent of exanthem subitum, and has also been linked with a variety of other diseases. The aim of this study was to investigate the role of HHV-6 in pneumonitis in children. METHODS: Formalin fixed, paraffin wax embedded lung tissue from 33 children (age range two months to 16 years) who died with pneumonitis was subjected to immunohistochemical staining for HHV-6 using an avidin-biotin method. RESULTS: Active HHV-6 infection was demonstrated in four children: a bone marrow transplant recipient with concomitant adenovirus infection, a patient with hepatitis of unknown aetiology, a patient with congenital anomalies, and a patient with congenital immunodeficiency. CONCLUSION: Accurate localisation of HHV-6 is possible in postmortem lung tissue. HHV-6 either alone or in combination with other pathogens may play a role in the development of pneumonitis.}, issn = {0021-9746}, URL = {https://jcp.bmj.com/content/49/10/802}, eprint = {https://jcp.bmj.com/content/49/10/802.full.pdf}, journal = {Journal of Clinical Pathology} }