PT  - JOURNAL ARTICLE
AU  - J R Neilson
AU  - W N Patton
AU  - M D Williams
AU  - E E Mayne
AU  - B J Boughton
TI  - Polycythaemia rubra vera transforming to acute lymphoblastic leukaemia with a common immunophenotype.
AID  - 10.1136/jcp.47.5.471
DP  - 1994 May 01
TA  - Journal of Clinical Pathology
PG  - 471--472
VI  - 47
IP  - 5
4099  - http://jcp.bmj.com/content/47/5/471.short
4100  - http://jcp.bmj.com/content/47/5/471.full
SO  - J Clin Pathol1994 May 01; 47
AB  - Lymphoblastic transformation of polycythaemia rubra vera is an extremely rare phenomenon. A case of a 76 year old man with polycythaemia rubra vera who developed acute lymphoblastic leukaemia (ALL) 16 years after his initial diagnosis is reported. Membrane markers showed a CD10 positive (common ALL) immunophenotype. To our knowledge this association has not been previously recorded. The rare occurrence of ALL in polycythaemia rubra vera may indicate that in a minority of patients clonal expansion of an abnormal pluripotent haemopoietic stem cell is responsible for the polycythaemia rubra vera disease phenotype.