PT  - JOURNAL ARTICLE
AU  - M Nagai
AU  - S Oda
AU  - M Iwamoto
AU  - K Marumoto
AU  - M Fujita
AU  - J Takahara
TI  - Granulocyte-colony stimulating factor concentrations in a patient with plasma cell dyscrasia and clinical features of chronic neutrophilic leukaemia.
AID  - 10.1136/jcp.49.10.858
DP  - 1996 Oct 01
TA  - Journal of Clinical Pathology
PG  - 858--860
VI  - 49
IP  - 10
4099  - http://jcp.bmj.com/content/49/10/858.short
4100  - http://jcp.bmj.com/content/49/10/858.full
SO  - J Clin Pathol1996 Oct 01; 49
AB  - In order to study the pathogenesis of plasma cell dyscrasias with associated clinical features of chronic neutrophilic leukaemia, the concentration of granulocyte-colony stimulating factor (G-CSF) was measured in a patient, a 73 year old man, who underwent steroid pulse therapy. High G-CSF concentrations and leucocyte counts prior to treatment declined rapidly on administration of dexamethazone, but rose subsequently. G-CSF was not detected in primary cultures of bone marrow cells, but large amounts of interleukin-6 were found in the culture supernatant. These observations suggest that the neutrophilia observed in the patient represented a reactive response to G-CSF secreted from abnormal plasma cells or stromal cells rather than the existence of a genuine myeloproliferative disorder.