PT  - JOURNAL ARTICLE
AU  - S R Smith
AU  - P G Middleton
AU  - P J Birch
AU  - L Morgan
AU  - P W Saunders
TI  - Longstanding proliferation of CD3 negative large granular lymphocytes preceding the development of high grade non-Hodgkin's lymphoma.
AID  - 10.1136/jcp.48.7.672
DP  - 1995 Jul 01
TA  - Journal of Clinical Pathology
PG  - 672--675
VI  - 48
IP  - 7
4099  - http://jcp.bmj.com/content/48/7/672.short
4100  - http://jcp.bmj.com/content/48/7/672.full
SO  - J Clin Pathol1995 Jul 01; 48
AB  - A patient with a persistent CD3 negative large granular lymphocyte (LGL) proliferation with immunophenotypic and functional characteristics of natural killer cells is described. The LGL proliferation persisted and six years after diagnosis the patient developed a high grade B cell non-Hodgkin's lymphoma. Molecular studies demonstrated clonal B cell populations in the peripheral blood, distinct from that identified in the lymphoma, both at presentation with non-Hodgkin's lymphoma and at complete remission following combination chemotherapy. It is postulated that T cell dysregulation associated with the CD3 negative LGL proliferation may have led to B cell dysfunction and loss of normal B cell control, with the subsequent development of a clonal B cell lymphoproliferative disorder.