PT  - JOURNAL ARTICLE
AU  - P A Gevenois
AU  - J Zanen
AU  - V de Maertelaer
AU  - P De Vuyst
AU  - P Dumortier
AU  - J C Yernault
TI  - Macroscopic assessment of pulmonary emphysema by image analysis.
AID  - 10.1136/jcp.48.4.318
DP  - 1995 Apr 01
TA  - Journal of Clinical Pathology
PG  - 318--322
VI  - 48
IP  - 4
4099  - http://jcp.bmj.com/content/48/4/318.short
4100  - http://jcp.bmj.com/content/48/4/318.full
SO  - J Clin Pathol1995 Apr 01; 48
AB  - AIMS--To propose a computerised image analysis based method for measuring, on paper mounted lung sections, the area macroscopically occupied by emphysema. METHODS--The study was based on the assessment of 69 lung sections prepared following a modified Gough-Wentworth technique. The results obtained from image analysis, point counting, and panel grading methods were compared, as was the repeatability of image analysis and panel grading. RESULTS--The results from image analysis and from point counting were not significantly different (p = 0.609) and significant quadratic regressions (r = 0.96, p < 0.001) were found between measurements from image analysis and from panel grading, the computerised technique being shown to be the most reproducible. CONCLUSIONS--Image analysis is a valuable and reproducible method to measure the area of lung macroscopically involved by emphysema.