PT  - JOURNAL ARTICLE
AU  - M Shimizu
AU  - T Matsumoto
AU  - M Hirokawa
AU  - Y Monobe
AU  - M Iida
AU  - T Manabe
TI  - Intraepithelial haemorrhage of the oesophagus: a terminal event in haematological disorders.
AID  - 10.1136/jcp.51.11.838
DP  - 1998 Nov 01
TA  - Journal of Clinical Pathology
PG  - 838--841
VI  - 51
IP  - 11
4099  - http://jcp.bmj.com/content/51/11/838.short
4100  - http://jcp.bmj.com/content/51/11/838.full
SO  - J Clin Pathol1998 Nov 01; 51
AB  - AIMS: To investigate the clinicopathological findings in cases with intraepithelial haemorrhage of the oesophagus (IHO). METHODS: Necropsy records and the histopathology findings in the oesophagus were reviewed for the period 1990 to 1995. Six cases (0.7%) of IHO were found among 919 necropsy cases. Clinical records of these patients and gross and microscopic slides were reviewed in detail. RESULTS: The ages of the IHO cases ranged from 42 to 82 years (average 68 years), with a male to female ratio of 1:2. All cases had underlying haematological disorders with thrombocytopenia, but disseminated intravascular coagulation was not evident in any case. Macroscopically, solitary (two cases) or multiple (four cases) haemorrhagic lesions ranging from 6 to 79 mm in size were identified within the distal oesophagus. Microscopically, there was no inflammatory infiltration, destruction of red blood cells, or submucosal scar formation. CONCLUSIONS: IHO seems to occur shortly before death as a terminal event in haematological disorders. Based on these observations, the term &quot;terminal IHO&quot; can be suggested for this type of oesophageal lesion.