TY - JOUR T1 - Intraepithelial haemorrhage of the oesophagus: a terminal event in haematological disorders. JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 838 LP - 841 DO - 10.1136/jcp.51.11.838 VL - 51 IS - 11 AU - M Shimizu AU - T Matsumoto AU - M Hirokawa AU - Y Monobe AU - M Iida AU - T Manabe Y1 - 1998/11/01 UR - http://jcp.bmj.com/content/51/11/838.abstract N2 - AIMS: To investigate the clinicopathological findings in cases with intraepithelial haemorrhage of the oesophagus (IHO). METHODS: Necropsy records and the histopathology findings in the oesophagus were reviewed for the period 1990 to 1995. Six cases (0.7%) of IHO were found among 919 necropsy cases. Clinical records of these patients and gross and microscopic slides were reviewed in detail. RESULTS: The ages of the IHO cases ranged from 42 to 82 years (average 68 years), with a male to female ratio of 1:2. All cases had underlying haematological disorders with thrombocytopenia, but disseminated intravascular coagulation was not evident in any case. Macroscopically, solitary (two cases) or multiple (four cases) haemorrhagic lesions ranging from 6 to 79 mm in size were identified within the distal oesophagus. Microscopically, there was no inflammatory infiltration, destruction of red blood cells, or submucosal scar formation. CONCLUSIONS: IHO seems to occur shortly before death as a terminal event in haematological disorders. Based on these observations, the term "terminal IHO" can be suggested for this type of oesophageal lesion. ER -