PT  - JOURNAL ARTICLE
AU  - Z Szekanecz
AU  - G K Haines
AU  - A E Koch
TI  - Differential expression of the urokinase receptor (CD87) in arthritic and normal synovial tissues.
AID  - 10.1136/jcp.50.4.314
DP  - 1997 Apr 01
TA  - Journal of Clinical Pathology
PG  - 314--319
VI  - 50
IP  - 4
4099  - http://jcp.bmj.com/content/50/4/314.short
4100  - http://jcp.bmj.com/content/50/4/314.full
SO  - J Clin Pathol1997 Apr 01; 50
AB  - AIM: To determine whether the urokinase plasminogen activator receptor (u-PAR; CD87) exhibits a possible pathogenic role in rheumatoid and osteoarthritis. METHODS: A semiquantitative, indirect immunoperoxidase histochemical analysis was performed on frozen synovial tissue sections. The recently characterised monoclonal antibody 10G7 recognising transfectants bearing u-PAR was used. Synovial tissue was obtained from 10 patients with rheumatoid arthritis, 10 patients with osteoarthritis, and four normal subjects. RESULTS: u-PAR was expressed on 70-90% of synovial tissue lining cells and subsynovial, interstitial macrophages from the arthritis patients, but only on a few myeloid cells from the normal subjects. It was also present on more endothelial cells from the rheumatoid and osteoarthritis patients, than from normal synovial tissue. CONCLUSIONS: Plasminogen activators are important in joint destruction underlying arthritis. The up-regulated expression of u-PAR in diseased versus normal synovial tissue suggests a role for this antigen in the inflammatory and angiogenic mechanisms underlying rheumatoid and osteoarthritis.