RT Journal Article SR Electronic T1 Nosocomial empyema caused by Clostridium difficile. JF Journal of Clinical Pathology JO J Clin Pathol FD BMJ Publishing Group Ltd and Association of Clinical Pathologists SP 172 OP 173 DO 10.1136/jcp.49.2.172 VO 49 IS 2 A1 A J Simpson A1 S S Das A1 S Tabaqchali YR 1996 UL http://jcp.bmj.com/content/49/2/172.abstract AB Pleural infection with Clostridium difficile is extremely rare. A case of nosocomial empyema following chest drain insertion in a 46 year old man is described. The potential of C difficile to cause extra-intestinal infections should be recognised and its isolation from other sites should not be ignored.