RT Journal Article
SR Electronic
T1 Apolipoprotein E alleles in women with severe pre-eclampsia.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 324
OP 325
DO 10.1136/jcp.51.4.324
VO 51
IS 4
A1 B Nagy
A1 J Rigó, Jr
A1 L Fintor
A1 I Karádi
A1 T Tóth
YR 1998
UL http://jcp.bmj.com/content/51/4/324.abstract
AB This study investigated the frequency of apolipoprotein E (apoE) alleles among women with severe pre-eclampsia. The presence of the three most common apoE alleles (epsilon 2, epsilon 3, epsilon 4) was determined by polymerase chain reaction-restriction fragment length polymorphism in three groups of white women: non-pregnant healthy (n = 101), pregnant healthy (n = 52), and pregnant with a diagnosis of severe pre-eclampsia (n = 54). The frequency of apo epsilon 2 was highest among women with severe pre-eclampsia (16.6%) followed by non-pregnant women (12.9%), and those experiencing a healthy pregnancy (10.6%). The higher frequency of the apo epsilon 2 allele detected among women with severe pre-eclampsia suggests that apoE may play a role in the development of pre-eclampsia.