RT Journal Article
SR Electronic
T1 Widespread neuroendocrine malignancy within the central nervous system: a diagnostic conundrum.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 440
OP 442
DO 10.1136/jcp.50.5.440
VO 50
IS 5
A1 D J Hopster
A1 S F Robinson
A1 L Chadwick
A1 J F Geddes
YR 1997
UL http://jcp.bmj.com/content/50/5/440.abstract
AB A 75 year old female presented with a sellar tumour, and was subsequently found also to have a cauda equina tumour, a parietal dural tumour, a pontine tumour, an intradural spinal tumour, and several vertebral body tumours. Histological examination revealed a neuroendocrine tumour forming cell nests surrounded by reticulin. There was moderate nuclear pleomorphism, prominent mitoses, and focal necrosis. Immunohistochemistry showed diffuse positive staining with cytokeratins, chromogranin and 5-hydroxytryptamine, and focal positive staining with S100. This case is an unusual and ultimately insoluble, diagnostic problem; however, the differential diagnoses include pituitary carcinoma, malignant paraganglioma, and atypical carcinoid.