RT Journal Article
SR Electronic
T1 Immunohistochemical localisation of advanced glycation end products in pulmonary fibrosis.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 515
OP 519
DO 10.1136/jcp.51.7.515
VO 51
IS 7
A1 T Matsuse
A1 E Ohga
A1 S Teramoto
A1 M Fukayama
A1 R Nagai
A1 S Horiuchi
A1 Y Ouchi
YR 1998
UL http://jcp.bmj.com/content/51/7/515.abstract
AB AIM: To investigate the presence and distribution of advanced glycation end products (AGE) in pulmonary fibrosis. METHODS: Lung tissue samples obtained from seven necropsy cases with idiopathic pulmonary fibrosis and seven with normal pulmonary parenchyma were examined immunohistochemically with a monoclonal antibody specific for AGE: 6D12. We also tested three cases with diffuse alveolar damage. RESULTS: All the specimens from cases with pulmonary fibrosis and diffuse alveolar damage showed strong AGE expression on macrophages. Lung specimens from normal parenchyma showed positive AGE immunoreactivity on macrophages from only two of seven cases. CONCLUSIONS: These findings suggest that AGE modified proteins accumulate in alveolar macrophages in patients with diffuse alveolar damage and idiopathic pulmonary fibrosis.