@article {Berg249, author = {J N Berg and J W Walter and U Thisanagayam and M Evans and F Blei and M Waner and A G Diamond and D A Marchuk and M E Porteous}, title = {Evidence for loss of heterozygosity of 5q in sporadic haemangiomas: are somatic mutations involved in haemangioma formation?}, volume = {54}, number = {3}, pages = {249--252}, year = {2001}, doi = {10.1136/jcp.54.3.249}, publisher = {BMJ Publishing Group}, abstract = {Background/Aims{\textemdash}Haemangiomas are common benign tumours of infancy that consist of rapidly proliferating endothelial cells. A locus for an autosomal dominant predisposition to haemangioma has been identified recently on chromosome 5q. This study aimed to investigate loss of heterozygosity on chromosomes 5 and 9 in haemangiomas. Methods{\textemdash}Sporadic proliferative phase haemangiomas were microdissected. Polymerase chain reaction amplification and analysis of microsatellite markers on chromosomes 5 and 9 was carried out. Results{\textemdash}There was a significant loss of heterozygosity for markers on chromosome 5q in haemangioma tissue, when compared with either markers from chromosome 5p (p \< 0.05) or markers from chromosome 9 (p \< 0.05). Conclusions{\textemdash}These results suggest that haemangioma formation might be associated with somatic mutational events, and provides evidence that a locus on 5q is involved in the formation of sporadic haemangiomas.}, issn = {0021-9746}, URL = {https://jcp.bmj.com/content/54/3/249}, eprint = {https://jcp.bmj.com/content/54/3/249.full.pdf}, journal = {Journal of Clinical Pathology} }