PT - JOURNAL ARTICLE AU - Y Sadahira AU - K Kumori AU - Y Mikami AU - T Otsuki AU - T Manabe AU - K Aoyama TI - Post-transplant malignant lymphoma with monoclonal immunoglobulin gene rearrangement and polyclonal Epstein-Barr virus episomes DP - 2001 Nov 01 TA - Journal of Clinical Pathology PG - 887--889 VI - 54 IP - 11 4099 - http://jcp.bmj.com/content/54/11/887.short 4100 - http://jcp.bmj.com/content/54/11/887.full SO - J Clin Pathol2001 Nov 01; 54 AB - This report describes the case of an 8 year old boy who developed ileocecal B cell lymphoma after liver transplantation. The patient underwent orthotropic liver transplantation for biliary atresia and had been given immunosuppressive drugs—cyclosporin A and tacrolimus hydrate. Six years after the liver transplantation, the patient had a sudden onset of fever and abdominal pain. Necropsy revealed an ileocecal mass that was a B cell lymphoma. Epstein-Barr virus (EBV) encoded RNA 1 was demonstrated in lymphoma cells and hyperplastic follicular germinal centre cells in various tissues. Although monoclonal immunoglobulin gene rearrangement was detected in the liver, EBV episomes were of polyclonal origin and lytic forms of EBV were also demonstrated by Southern blotting. Immunohistochemically, lymphoma cells were positive for p53 but negative for latent membrane protein 1 and EBV nuclear antigen 2. These findings suggested that this B cell lymphoma might have occurred sporadically, regardless of EBV infection.