RT Journal Article
SR Electronic
T1 Immunohistochemical detection of steroid receptors in breast cancer: a working protocol
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 634
OP 635
DO 10.1136/jcp.53.8.634
VO 53
IS 8
A1 Leake, Robin
A1 Barnes, Diana
A1 Pinder, Sarah
A1 Ellis, Ian
A1 Anderson, Liz
A1 Anderson, Tom
A1 Adamson, Ruth
A1 Rhodes, Tony
A1 Miller, Keith
A1 Walker, Rosemary
YR 2000
UL http://jcp.bmj.com/content/53/8/634.abstract
AB The biochemical assay for the oestrogen receptor has shown the clinical value of knowing the concentration of the receptor within tissue. The immunohistochemical assay is rapidly taking over from the biochemical assay. Therefore, it is vital to have an equivalent scoring system that will have the same predictive value. This paper reports both a practical protocol and a scoring system that should achieve this aim. This approach should be applicable to many more biomarkers detected by immunohistochemistry.