PT  - JOURNAL ARTICLE
AU  - Rodolfo Montironi
AU  - Roberta Mazzucchelli
AU  - Ferran Algaba
AU  - Antonio Lopez-Beltran
TI  - Morphological identification of the patterns of prostatic intraepithelial neoplasia and their importance
AID  - 10.1136/jcp.53.9.655
DP  - 2000 Sep 01
TA  - Journal of Clinical Pathology
PG  - 655--665
VI  - 53
IP  - 9
4099  - http://jcp.bmj.com/content/53/9/655.short
4100  - http://jcp.bmj.com/content/53/9/655.full
SO  - J Clin Pathol2000 Sep 01; 53
AB  - High grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostatic carcinoma. PIN has a high predictive value as a marker for carcinoma, and its identification in biopsy specimens warrants repeat biopsy for concurrent or subsequent carcinoma. The only methods of detection are biopsy and transurethral resection; PIN does not greatly raise the concentration of serum prostate specific antigen (PSA) or its derivatives, does not induce a palpable mass, and cannot be detected by ultrasound. Androgen deprivation decreases the prevalence and extent of PIN, suggesting that this form of treatment might play a role in chemoprevention. Radiotherapy is also associated with a decreased incidence of PIN.