RT Journal Article
SR Electronic
T1 Morphological identification of the patterns of prostatic intraepithelial neoplasia and their importance
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 655
OP 665
DO 10.1136/jcp.53.9.655
VO 53
IS 9
A1 Montironi, Rodolfo
A1 Mazzucchelli, Roberta
A1 Algaba, Ferran
A1 Lopez-Beltran, Antonio
YR 2000
UL http://jcp.bmj.com/content/53/9/655.abstract
AB High grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostatic carcinoma. PIN has a high predictive value as a marker for carcinoma, and its identification in biopsy specimens warrants repeat biopsy for concurrent or subsequent carcinoma. The only methods of detection are biopsy and transurethral resection; PIN does not greatly raise the concentration of serum prostate specific antigen (PSA) or its derivatives, does not induce a palpable mass, and cannot be detected by ultrasound. Androgen deprivation decreases the prevalence and extent of PIN, suggesting that this form of treatment might play a role in chemoprevention. Radiotherapy is also associated with a decreased incidence of PIN.