PT  - JOURNAL ARTICLE
AU  - P Dey
TI  - Aneuploidy and malignancy: an unsolved equation
AID  - 10.1136/jcp.2004.018952
DP  - 2004 Dec 01
TA  - Journal of Clinical Pathology
PG  - 1245--1249
VI  - 57
IP  - 12
4099  - http://jcp.bmj.com/content/57/12/1245.short
4100  - http://jcp.bmj.com/content/57/12/1245.full
SO  - J Clin Pathol2004 Dec 01; 57
AB  - Aneuploidy is frequently noted in malignant tumours. There is much controversy about its cause and effect in relation to malignant tumours. Failure of the spindle checkpoint caused by mutation of the responsible genes may be one of the important factors for the development of aneuploidy. Telomere dysfunction may also be a possible source of failure of cytokinesis resulting in aneuploidy. Evidence such as tumour specific aneuploidy, presence of aneuploidy in various preneoplastic conditions, increased frequency of genetic instability in aneuploid cell lines compared with diploid cells, and mutation of mitotic checkpoint genes suggests that aneuploidy possibly plays an active role in carcinogenesis. In this brief review, the various aspects of aneuploidy with special emphasis on its mechanism of development and impact on progression of cancer are discussed.