TY - JOUR T1 - Insertion of the CCND1 gene into the IgH locus in a case of leukaemic small cell mantle lymphoma with normal chromosomes 11 and 14 JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 798 LP - 800 DO - 10.1136/jcp.56.10.798 VL - 56 IS - 10 AU - A Aventín AU - J Nomdedéu AU - J Briones AU - I Espinosa AU - R Bordes AU - J Sierra Y1 - 2003/10/01 UR - http://jcp.bmj.com/content/56/10/798.abstract N2 - The t(11;14)(q13;q32) translocation is considered to be the cytogenetic hallmark of mantle cell lymphoma. This report describes a case of leukaemic mantle cell lymphoma in which conventional cytogenetics on stimulated peripheral blood cells showed a 46,XY, t(1;12)(p21;q23)/46,XY karyotype. Fluorescence in situ hybridisation analysis using a dual colour immunoglobulin heavy chain (IgH)/CCND1 probe showed a fusion hybridisation signal on one normal chromosome 14, indicating that an insertion of the CCND1 gene into the 14q32/IgH locus had taken place. Overexpression of the cyclin D1 protein was demonstrated on bone marrow trephine by immunohistochemical staining. ER -