PT  - JOURNAL ARTICLE
AU  - L Venkatraman
AU  - J R Goepel
AU  - K Steele
AU  - S P Dobbs
AU  - R W Lyness
AU  - W G McCluggage
TI  - Soft tissue, pelvic, and urinary bladder leiomyosarcoma as second neoplasm following hereditary retinoblastoma
AID  - 10.1136/jcp.56.3.233
DP  - 2003 Mar 01
TA  - Journal of Clinical Pathology
PG  - 233--236
VI  - 56
IP  - 3
4099  - http://jcp.bmj.com/content/56/3/233.short
4100  - http://jcp.bmj.com/content/56/3/233.full
SO  - J Clin Pathol2003 Mar 01; 56
AB  - This report describes two patients who developed leiomyosarcomas, one involving the subcutaneous tissue of the thigh and the pelvic soft tissues and the other the urinary bladder, following hereditary retinoblastoma 36 and 38 years earlier, respectively. There is an increased risk of the development of sarcoma, most commonly osteosarcoma, as a second malignancy following hereditary retinoblastoma. Leiomyosarcoma developing as a second malignancy has rarely been reported and most have occurred in the field of previous radiotherapy. The literature on leiomyosarcoma occurring as a second neoplasm following retinoblastoma is reviewed.