TY - JOUR T1 - Meningococcal meningitis in two patients with primary antibody deficiency treated with replacement intravenous immunoglobulin JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 1191 LP - 1193 DO - 10.1136/jcp.2005.031054 VL - 59 IS - 11 AU - S Lear AU - E Eren AU - J Findlow AU - R Borrow AU - D Webster AU - S Jolles Y1 - 2006/11/01 UR - http://jcp.bmj.com/content/59/11/1191.abstract N2 - The current treatment of primary antibody deficiency (PAD) is the early recognition of the condition and replacement immunoglobulin combined with prompt treatment of infections and complications. The route of administration (intravenous or subcutaneous), dose and frequency of administration of immunoglobulin still vary between centres and countries. Most infections in patients with PAD are reduced but not entirely prevented by replacement immunoglobulin, with sinopulmonary infections accounting for the bulk of the remainder. Although there have been reports of meningitis in patients with PAD before replacement treatment, we describe the first two cases of bacterial meningitis (group B Neisseria meningitidis) on adequate immunoglobulin replacement and discuss the involvement of potential cofactors. ER -