PT - JOURNAL ARTICLE AU - M Melissari AU - A Lopez Beltran AU - R Mazzucchelli AU - E Froio AU - D G Bostwick AU - R Montironi TI - High grade prostatic intraepithelial neoplasia with squamous differentiation AID - 10.1136/jcp.2005.028241 DP - 2006 Apr 01 TA - Journal of Clinical Pathology PG - 437--439 VI - 59 IP - 4 4099 - http://jcp.bmj.com/content/59/4/437.short 4100 - http://jcp.bmj.com/content/59/4/437.full SO - J Clin Pathol2006 Apr 01; 59 AB - An unusual variant of prostatic intraepithelial neoplasia with prominent and extensive squamous differentiation is described. The lesion was identified in the transition zone of a 79 year old man with a three year history of increasing urinary obstructive symptoms and a clinical diagnosis of benign prostatic hyperplasia who underwent simple prostatectomy. Two years after surgery, prostatic biopsies showed atrophy and mild chronic inflammation, with no evidence of malignancy. This unusual intraepithelial lesion seems not to have been described before and may represent a new variant of high grade prostatic intraepithelial neoplasia (HGPIN) with squamous differentiation.