RT Journal Article
SR Electronic
T1 Coeliac disease: an update for pathologists
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 1008
OP 1016
DO 10.1136/jcp.2005.035345
VO 59
IS 10
A1 Dickson, B C
A1 Streutker, C J
A1 Chetty, R
YR 2006
UL http://jcp.bmj.com/content/59/10/1008.abstract
AB Coeliac disease is the manifestation of an immune hypersensitivity reaction towards gluten and related proteins, in genetically predisposed people. Although the precise pathogenesis of this condition remains to be fully elucidated, it is probably multifactorial in origin. The diagnosis of coeliac disease has traditionally depended on intestinal biopsies alone; nowadays, the diagnosis has been expanded to include an array of serological markers. This review is intended to offer pathologists an update of the relevant history and immunopathology pertaining to coeliac disease and also to offer recommendations on the ongoing responsibilities of the pathologist in the diagnosis and reporting of coeliac disease.