PT  - JOURNAL ARTICLE
AU  - Best-Aguilera, C R
AU  - Vazquez-Del Mercado, M
AU  - Muñoz-Valle, J F
AU  - Herrera-Zarate, L
AU  - Navarro-Hernandez, R E
AU  - Martin-Marquez, B T
AU  - Oregon-Romero, E
AU  - Ruiz-Quezada, S
AU  - Bonilla, G M
AU  - Lomeli-Guerrero, A
TI  - Massive myeloid sarcoma affecting the central nervous system, mediastinum, retroperitoneum, liver, and rectum associated with acute myeloblastic leukaemia: a case report
AID  - 10.1136/jcp.2003.015651
DP  - 2005 Mar 01
TA  - Journal of Clinical Pathology
PG  - 325--327
VI  - 58
IP  - 3
4099  - http://jcp.bmj.com/content/58/3/325.short
4100  - http://jcp.bmj.com/content/58/3/325.full
SO  - J Clin Pathol2005 Mar 01; 58
AB  - Myeloid sarcomas are extramedullary tumours with granulocytic precursors. When associated with acute myelogenous leukaemia (AML), these tumours usually affect no more than two different extramedullary regions. This report describes a myeloid sarcoma associated with AML with tumour formation at five anatomical sites. The patient was a 37 year old man admitted in September 1999 with a two month history of weight loss, symptoms of anaemia, rectal bleeding, and left facial nerve palsy. The anatomical sites affected were: the rectum, the right lobe of the liver, the mediastinum, the retroperitoneum, and the central nervous system. A bone marrow smear was compatible with AML M2. Flow cytometry showed that the peripheral blood was positive for CD4, CD11, CD13, CD14, CD33, CD45, and HLA-DR. A karyotypic study of the bone marrow revealed an 8;21 translocation. The presence of multiple solid tumours in AML is a rare event. Enhanced expression of cell adhesion molecules may be the reason why some patients develop myeloid sarcomas.