RT Journal Article
SR Electronic
T1 Massive myeloid sarcoma affecting the central nervous system, mediastinum, retroperitoneum, liver, and rectum associated with acute myeloblastic leukaemia: a case report
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 325
OP 327
DO 10.1136/jcp.2003.015651
VO 58
IS 3
A1 Best-Aguilera, C R
A1 Vazquez-Del Mercado, M
A1 Muñoz-Valle, J F
A1 Herrera-Zarate, L
A1 Navarro-Hernandez, R E
A1 Martin-Marquez, B T
A1 Oregon-Romero, E
A1 Ruiz-Quezada, S
A1 Bonilla, G M
A1 Lomeli-Guerrero, A
YR 2005
UL http://jcp.bmj.com/content/58/3/325.abstract
AB Myeloid sarcomas are extramedullary tumours with granulocytic precursors. When associated with acute myelogenous leukaemia (AML), these tumours usually affect no more than two different extramedullary regions. This report describes a myeloid sarcoma associated with AML with tumour formation at five anatomical sites. The patient was a 37 year old man admitted in September 1999 with a two month history of weight loss, symptoms of anaemia, rectal bleeding, and left facial nerve palsy. The anatomical sites affected were: the rectum, the right lobe of the liver, the mediastinum, the retroperitoneum, and the central nervous system. A bone marrow smear was compatible with AML M2. Flow cytometry showed that the peripheral blood was positive for CD4, CD11, CD13, CD14, CD33, CD45, and HLA-DR. A karyotypic study of the bone marrow revealed an 8;21 translocation. The presence of multiple solid tumours in AML is a rare event. Enhanced expression of cell adhesion molecules may be the reason why some patients develop myeloid sarcomas.