TY - JOUR T1 - Gastric MALT lymphoma with t(14;18)(q32;q21) involving <em>IGH</em> and <em>BCL2</em> genes that responded to <em>Helicobacter pylori</em> eradication JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 1171 LP - 1173 DO - 10.1136/jcp.2007.048207 VL - 60 IS - 10 AU - Shotaro Nakamura AU - Hongtao Ye AU - Chris M Bacon AU - Hongxiang Liu AU - Alison Goatly AU - Takayuki Matsumoto AU - Hideki Koga AU - Junji Umeno AU - Yutaka Ohji AU - Takashi Yao AU - Tsukasa Nakahara AU - Mitsuo Iida AU - Ming-Qing Du Y1 - 2007/10/01 UR - http://jcp.bmj.com/content/60/10/1171.abstract N2 - Four recurrent chromosomal translocations are recognised in mucosa-associated lymphoid tissue (MALT) lymphomas: t(11;18)/API2-MALT1, t(1;14)/IGH-BCL10, t(14;18)/IGH-MALT1 and t(3;14)/IGH-FOXP1. In contrast, t(14;18)/IGH-BCL2, the genetic hallmark of follicular lymphoma, has been observed in only rare cases of MALT lymphoma. Oesophagogastroduodenoscopy revealed an ulcer in erythematous granular mucosa at the gastric corpus in a 55-year-old man. A diagnosis of MALT lymphoma was made on the basis of typical histological and immunohistochemical features of biopsy specimens: a diffuse infiltrate of centrocyte-like cells surrounding reactive lymphoid follicles and forming lymphoepithelial lesions, and a CD20+, IgD−, CD5−, CD10−, Bcl6−, cyclinD1− immunophenotype. Four months after the successful eradication of Helicobacter pylori, there was endoscopic regression with probable minimal residual disease detected by biopsy, but histological relapse was recognised 12 months after eradication. Interphase fluorescence in situ hybridisation revealed t(14;18)/IGH-BCL2, but not the translocations typically seen in MALT lymphoma. This is the first report of a gastric MALT lymphoma with t(14;18)/IGH-BCL2 that responded to H pylori eradication. Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is genetically characterised by the recurrent translocations t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH, t(14;18)(q32;q21)/IGH-MALT1 and t(3;14)(p14;q32)/FOXP1-IGH.1 2 Recent evidence suggests that at least some of these translocations may be associated with distinct clinicopathological features.1 3 The t(14;18)(q32;q21)/IGH-BCL2 is found in the majority of follicular lymphomas and some diffuse large B-cell lymphomas.4 However, MALT lymphomas carrying this translocation are extremely rare and their clinical features are virtually unknown. A 55-year-old asymptomatic man underwent oesophagogastroduodenoscopy (OGD) as screening for gastric carcinoma. OGD revealed an open ulcer with surrounding granular erythematous mucosa in the upper corpus (fig 1A … ER -