PT  - JOURNAL ARTICLE
AU  - B Furusato
AU  - I L Rosner
AU  - D Osborn
AU  - A Ali
AU  - S Srivastava
AU  - C J Davis
AU  - I A Sesterhenn
AU  - D G McLeod
TI  - Do patients with low volume prostate cancer have prostate specific antigen recurrence following radical prostatectomy?
AID  - 10.1136/jcp.2008.057794
DP  - 2008 Sep 01
TA  - Journal of Clinical Pathology
PG  - 1038--1040
VI  - 61
IP  - 9
4099  - http://jcp.bmj.com/content/61/9/1038.short
4100  - http://jcp.bmj.com/content/61/9/1038.full
SO  - J Clin Pathol2008 Sep 01; 61
AB  - Aims: The objective of this study was to determine the incidence of prostate specific antigen (PSA) relapse in patients with low volume prostate cancer following radical prostatectomy.Methods: Between 1993 and 2001, 50 of 717 patients had total tumour volumes of less than 0.5 cm3 following radical prostatectomy. Biochemical recurrence was defined as two consecutive values of serum PSA levels of 0.2 ng/ml or greater.Results: Median follow-up of the 50 patients was 58 months. In five of the 50 patients (10%), PSA recurrence was observed. All of these five cases had Gleason score of 3+3 (well and/or moderately differentiated), organ confined and surgical margin negative tumours. In three of the five cases, capsular incision resulted in benign glands extending into the surgical margin.Conclusions: Five of 50 cases had PSA failure. In three of the five patients, benign glands located in the margin could explain the “PSA recurrence”. However, in the other two patients, none of the pathological parameters correlated with measurable PSA levels. The explanation for their PSA failure is unclear.