PT  - JOURNAL ARTICLE
AU  - Michal Nowicki
AU  - Danuta Ostalska-Nowicka
AU  - Beata Kondraciuk
AU  - Bogdan Miskowiak
TI  - The significance of substance P in physiological and malignant haematopoiesis
AID  - 10.1136/jcp.2006.041475
DP  - 2007 Jul 01
TA  - Journal of Clinical Pathology
PG  - 749--755
VI  - 60
IP  - 7
4099  - http://jcp.bmj.com/content/60/7/749.short
4100  - http://jcp.bmj.com/content/60/7/749.full
SO  - J Clin Pathol2007 Jul 01; 60
AB  - The role of substance P (SP) in physiological haematopoiesis is well established. However, it also seems to be important in the neoplastic transformation of bone marrow, leading to the development of acute leukaemia in children, and also metastases to bone marrow of solid tumours (particularly neuroblastoma and breast cancer) in early stages of these diseases. This review summarises the available data on SP involvement in both processes. In the future, SP antagonists may be used as anti-neoplastic drugs, for example by direct or indirect blocking of tumour cell proliferation through inhibition of growth factor production and interleukin-1b synthesis.