RT Journal Article
SR Electronic
T1 Mast-cell sarcoma of the tibia
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 424
OP 425
DO 10.1136/jcp.2006.040857
VO 60
IS 4
A1 Luka Brčić
A1 Lovorka Batelja Vuletić
A1 Jasminka Stepan
A1 Aleksandra Bonevski
A1 Gordana Jakovljević
A1 Slavko Gašparov
A1 Ksenija Marjanović
A1 Sven Seiwerth
YR 2007
UL http://jcp.bmj.com/content/60/4/424.abstract
AB The mast-cell sarcoma of a bone is described here for the first time. The tumour presented in a 4-year-old boy, with pain, oedema and deformation of his right lower leg. Radiological findings revealed a destructive tumourous mass. Histopathological examination showed the tumour to be composed of large, atypical cells, with hyperchromatic oval and polygonal nuclei. The cytoplasm around them was eosinophilic with many basophilic and toluidine-blue-positive granules. These atypical mast cells were positive for chloroacetate esterase, c-kit, tryptase and negative for myeloperoxidase. The primary disease quickly progressed to mast-cell leukaemia, and despite intensive chemotherapy the patient died 18 months after first symptoms.