PT  - JOURNAL ARTICLE
AU  - Patrick J Twomey
AU  - Adie Viljoen
AU  - Ivan M House
AU  - Timothy M Reynolds
AU  - Anthony S Wierzbicki
TI  - Copper:caeruloplasmin ratio
AID  - 10.1136/jcp.2006.041756
DP  - 2007 Apr 01
TA  - Journal of Clinical Pathology
PG  - 441--442
VI  - 60
IP  - 4
4099  - http://jcp.bmj.com/content/60/4/441.short
4100  - http://jcp.bmj.com/content/60/4/441.full
SO  - J Clin Pathol2007 Apr 01; 60
AB  - Investigation of copper status can be a diagnostic challenge. The non-caeruloplasmin-bound copper (NCC) has deficiencies; accordingly, the copper:caeruloplasmin ratio has been suggested as an alternative index of copper status. A reference interval for this index was derived. In addition to making the interpretation of copper easier, the copper:caeruloplasmin ratio should also enable adjustment for relatively high caeruloplasmin concentrations without recourse to producing gender- and age-derived intervals. The copper:caeruloplasmin ratio has weaknesses similar to those identified for NCC in that immunological methods used for caeruloplasmin can cross react with apocaeruloplasmin and there is no standardised method for caeruloplasmin. Caeruloplasmin assays also have uncertainty from precision, bias and specificity and, accordingly, method-related differences may have a large effect on the copper:caeruloplasmin ratio in a manner similar to the NCC.