TY - JOUR T1 - Contribution of the Epstein–Barr virus to the molecular pathogenesis of Hodgkin lymphoma JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 1342 LP - 1349 DO - 10.1136/jcp.2007.050146 VL - 60 IS - 12 AU - G Kapatai AU - P Murray Y1 - 2007/12/01 UR - http://jcp.bmj.com/content/60/12/1342.abstract N2 - Although the morphology of the pathognomonic Reed–Sternberg cells of Hodgkin lymphoma (HL) was described over a century ago, it was not until recently that their origin from B lymphocytes was recognised. The demonstration that a proportion of cases of HL harbour the Epstein–Barr virus (EBV) and that its genome is monoclonal in these tumours suggests that the virus contributes to the development of HL in some cases. This review summarises current knowledge of the pathogenesis of HL with particular emphasis on the association with EBV. ER -