RT Journal Article SR Electronic T1 Epstein–Barr virus and Burkitt lymphoma JF Journal of Clinical Pathology JO J Clin Pathol FD BMJ Publishing Group Ltd and Association of Clinical Pathologists SP 1397 OP 1402 DO 10.1136/jcp.2007.047977 VO 60 IS 12 A1 Brady, G A1 MacArthur, G J A1 Farrell, P J YR 2007 UL http://jcp.bmj.com/content/60/12/1397.abstract AB Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and immunodeficiency-associated variants. It has been known for many years that the fundamental transforming event in BL is the translocation of the MYC gene, and the events that bring about this translocation and those that allow cells to survive with the constitutive expression of MYC have been the subject of intense investigation. Epstein–Barr virus (EBV) infection, malaria, immunodeficiency and spontaneous, somatic mutation can all contribute to the origin and maintenance of this cancer and their mechanisms are the subject of this review.