PT - JOURNAL ARTICLE AU - S Nagata AU - S Aishima AU - K Fukuzawa AU - H Takagi AU - H Yonemasu AU - Y Iwashita AU - T Kinoshita AU - K Wakasugi TI - Adenomatoid tumour of the liver AID - 10.1136/jcp.2007.054684 DP - 2008 Jun 01 TA - Journal of Clinical Pathology PG - 777--780 VI - 61 IP - 6 4099 - http://jcp.bmj.com/content/61/6/777.short 4100 - http://jcp.bmj.com/content/61/6/777.full SO - J Clin Pathol2008 Jun 01; 61 AB - An unusual primary adenomatoid tumour arising in the normal liver is described. Hepatectomy was performed, and the patient is alive and free of disease 1 year postsurgery. Grossly, the tumour showed a haemorrhagic cut surface with numerous microcystic structures. Histological examination revealed cystic or angiomatoid spaces of various sizes lined by cuboidal, low-columnar, or flattened epithelioid cells with vacuolated cytoplasm and round to oval nuclei. The epithelioid cells were entirely supported by proliferated capillaries and arteries together with collagenous stroma. Immunohistochemical studies showed that the epithelioid cells were strongly positive for a broad spectrum of cytokeratins (AE1/AE3, CAM5.2, epithelial membrane antigen and cytokeratin 7) and mesothelial markers (calretinin, Wilms’ tumour 1 and D2-40). These cells were negative for Hep par-1, carcinoembryonic antigen, neural cell adhesion molecule, CD34, CD31 and HMB45. Atypically, abundant capillaries were observed; however, the cystic proliferation of epithelioid cells with vacuoles and immunohistochemical profile of the epithelioid element were consistent with hepatic adenomatoid tumour.