RT Journal Article
SR Electronic
T1 RNA interference screening demystified
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 195
OP 200
DO 10.1136/jcp.2008.058735
VO 62
IS 3
A1 C J Lord
A1 S A Martin
A1 A Ashworth
YR 2009
UL http://jcp.bmj.com/content/62/3/195.abstract
AB Genetic screens, where the effects of modifying gene function on cell behaviour are assessed in a systematic fashion, have for some time provided useful information to those interested in disease pathogenesis and treatment. Genetic screens exploiting the phenomenon of RNA interference (RNAi) are now becoming commonplace. This article explains the different RNAi screen formats and describes some of the applications of RNAi screening that may be pertinent to the research pathologist.