TY - JOUR T1 - Preliminary study on the correlation between grading and histology of solitary pulmonary nodules and contrast enhancement and [<sup>18</sup>F]fluorodeoxyglucose standardised uptake value after evaluation by dynamic multiphase CT and PET/CT JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 114 LP - 119 DO - 10.1136/jcp.2010.076562 VL - 64 IS - 2 AU - Salvatore Cappabianca AU - Annamaria Porto AU - Mario Petrillo AU - Barbara Greco AU - Alfonso Reginelli AU - Francesco Ronza AU - Francesca Setola AU - Giovanni Rossi AU - Andrea Di Matteo AU - Roberto Muto AU - Maria Luisa De Rimini AU - Sergio Piccolo AU - Mara Catalano AU - Pietro Muto AU - Nicoletta De Rosa AU - Enrica Barra AU - Ilaria De Rosa AU - Francesca Antinolfi AU - Giuseppe Antinolfi AU - Mario Caputi AU - Luca Brunese AU - Roberto Grassi AU - Antonio Rotondo Y1 - 2011/02/01 UR - http://jcp.bmj.com/content/64/2/114.abstract N2 - Aim To evaluate whether the histology and grading of solitary pulmonary nodules (SPNs) correlated with the results of dynamic multiphase multidetector CT (MDCT) and the [18F]fluorodeoxyglucose standardised uptake value (SUV) in 30 patients.Methods Chest x-rays of 270 patients with incidentally detected SPNs were retrospectively evaluated. Thirty patients with histologically proven SPNs were enrolled. On MDCT and positron emission tomography (PET)/CT images, two experts measured the density of nodules in all perfusion phases and the SUV. Net enhancement (NE) was calculated by subtracting peak pre-contrast density from peak post-contrast density. The Pearson test was used to correlate nodule NE, SUV, grading, histology and diameter.Results Of the 30 malignant SPNs, six were classified as G1 (median NE, 31.5 Hounsfield units (HU); median SUV, 4.8 units), 15 were classified as G2 (median NE, 49 HU; median SUV, 6 units), and nine were classified as G3 (median NE, 32 HU; median SUV, 4.5 units). A highly negative correlation was found in G3 SPNs between NE and the corresponding diameters (r=−0.834; p=0.00524). NE increased with the increase in diameter (r=0.982; p=0.284). SUV increased as the SPN diameter increased (r=0.789; p=0.421). NE and SUV were higher in G2 than G1 SPNs, and lower in G2 than G3 SPNs (r=0.97; p=0.137).Conclusions The significant correlation in dedifferentiated (G3) SPNs between NE and diameter (r=−0.834; p=0.00524) supports the theory that stroma and neoangiogenesis are fundamental in SPN growth. The highly negative correlation between NE and diameter demonstrates a net decrease in perfusion despite an increase in dimension. The multidisciplinary approach used herein may result in a more precise prognosis and consequently a better therapeutic outcome, particularly in patients with undifferentiated lung cancer. ER -