TY - JOUR T1 - Spontaneous regression of natural killer cell lymphoma JF - Journal of Clinical Pathology JO - J Clin Pathol SP - 647 LP - 650 DO - 10.1136/jcp.2008.062976 VL - 62 IS - 7 AU - Y Isobe AU - N Aritaka AU - M Sasaki AU - K Oshimi AU - K Sugimoto Y1 - 2009/07/01 UR - http://jcp.bmj.com/content/62/7/647.abstract N2 - Spontaneous tumour regression is extremely rare in aggressive lymphoma. A case of natural killer (NK) cell lymphoma with cutaneous manifestation showed an indolent clinical course, and the relapsed nodular lesion disappeared spontaneously without any treatment. Although only small number of T cells were present in the primary skin lesion, there was massive CD8-positive cytotoxic T cell infiltration in the relapsed lesion. This is believed to be the first report of an abscopal effect on NK cell lymphoma. Infiltration of cytotoxic T cells strongly suggests immunological attack against the lymphoma cells. ER -