RT Journal Article
SR Electronic
T1 Handling and reporting of nephrectomy specimens for adult renal tumours: a survey by the European Network of Uropathology
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 106
OP 113
DO 10.1136/jclinpath-2011-200339
VO 65
IS 2
A1 Algaba, Ferran
A1 Delahunt, Brett
A1 Berney, Daniel M
A1 Camparo, Philippe
A1 Compérat, Eva
A1 Griffiths, David
A1 Kristiansen, Glen
A1 Lopez-Beltran, Antonio
A1 Martignoni, Guido
A1 Moch, Holger
A1 Montironi, Rodolfo
A1 Varma, Murali
A1 Egevad, Lars
YR 2012
UL http://jcp.bmj.com/content/65/2/106.abstract
AB Aim To collect information on current practices of European pathologists for the handling and reporting of nephrectomy specimens with renal tumours.Methods and Results A questionnaire was circulated to the members of the European Network of Uropathology, which consists of 343 pathologists in 15 European countries. Replies were received from 48% of members. These replies indicated that nephrectomy specimens are most often received in formalin. Lymph nodes are found in less than 5% of nephrectomy specimens. All respondents give an objective measure of tumour size, most commonly in three diameters. The most common method to search for capsule penetration is to slice tissue outside the tumour perpendicularly into the tumour. The most common sampling algorithm from tumours greater than 2 cm is one section for every centimetre of maximum tumour diameter. Most respondents use the 2004 WHO renal tumour classification although only slightly over half consider small papillary tumours malignant if the diameter is greater than 5 mm. The Fuhrman grading system is widely used. Almost all use immunohistochemistry for histological typing in some cases, while only 7% always use it. The most utilised special stains are CK7 (95%), CD10 (93%), vimentin (86%), HMB45 (68%), c-kit (61%) and Hale's colloidal iron (52%). Only 18% use other ancillary techniques for diagnosis in difficult cases.Conclusions While most pathologists appear to follow published guidelines for reporting renal carcinoma, there is still a need for the development of consensus and further standardisation of practice for contentious areas of specimen handling and reporting.