RT Journal Article
SR Electronic
T1 Whole slide images for primary diagnostics in dermatopathology: a feasibility study
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 152
OP 158
DO 10.1136/jclinpath-2011-200277
VO 65
IS 2
A1 Shaimaa Al-Janabi
A1 André Huisman
A1 Aryan Vink
A1 Roos J Leguit
A1 G Johan A Offerhaus
A1 Fiebo J W ten Kate
A1 Marijke R van Dijk
A1 Paul J van Diest
YR 2012
UL http://jcp.bmj.com/content/65/2/152.abstract
AB Background During the last decade, whole slide images (WSI) have been used in many areas of pathology such as teaching, research, digital archiving, teleconsultation and quality assurance testing. However, WSI have not regularly been used for routine diagnosis, because of the lack of validation studies.Aim To test the validity of using WSI for primary diagnosis of skin diseases.Materials and methods 100 skin biopsies and resections which had been diagnosed light microscopically one year previously were scanned at 20× magnification, and rediagnosed by six pathologists (every pathologist assessed his own cases), having the original clinical information available, but blinded to the original diagnoses. The WSI diagnoses were compared to the initial light microscopy diagnosis and classified as concordant, slightly discordant (without clinical consequences) or discordant.Results The light microscopy and the WSI based diagnosis were concordant in 94% of the cases. The light microscopy and WSI diagnosis were slightly discordant in 6% of the cases. For one of the slightly discrepant cases the WSI diagnosis was considered better, while the original diagnosis was preferred for the other five cases. There were no discordant cases with clinical or prognostic implications.Conclusion Primary histopathological diagnosis of skin biopsies and resections can be done digitally using WSI.